Our Resident Network

Meet Our Residents

LabCentral has generated significant interest from entrepreneurs and startups working on groundbreaking science who are eager to join LabCentral, a first-of-its-kind, fully resourced and equipped life-sciences laboratory space. Participants are chosen through a competitive process, where only the highest-potential applicants are selected in keeping with our mission.

Absco

AbscoTx is developing a proprietary, injectable, intratumoral drug delivery platform based on research out of the Traverso lab at MIT/BWH and Interventional Radiology at MGH. Our technology acts as a personalized "cancer vaccine" by training the immune system to fight solid cancers both locally and at distant metastatic sites. This therapy modifies the local tumor microenvironment and can elicit a strong, targeted immune response against any type of solid tumor, without causing systemic toxicities ($111B market, CAGR 11%, lead indication in metastatic colorectal cancer).

We solve challenges with previous intratumoral therapies -- such as high drug leakage out of the tumor, lack of image guidance to confirm delivery, and the need for frequent repeat injections -- using an injectable and imageable thermoresponsive polymer that solidifies in the tumor, ensuring precise and sustained drug retention. Our approach works with standard interventional radiology techniques, enabling treatment of advanced-stage tumors anywhere in the body. Unlike CAR-T cells or antibody-drug conjugates, our approach generates a robust immune response against multiple tumor antigens, reducing the likelihood of tumor mutations leading to antigen escape and treatment resistance.

Our lead asset results show strong and durable complete response without recurrence in an immunotherapy resistant (MSI-low) dual-tumor colorectal cancer model, with complete resolution of the treated and untreated tumors in responding animals. We can deliver small hydrophobic molecules and biologic agents via our platform, and we are in discussions with potential strategic partners to use their immune stimulant drugs intratumorally with our system. Based on regulatory analysis with Halloran, our lead asset will follow a streamlined 505(b)(2) pathway, with a clear preclinical development path to Investigational New Drug (IND)-clearance within 3 years. Upon clinical approval, we anticipate premium pricing given the lack of curative-intent alternatives in the market (comparator $65-100k/patient for Imlygic for melanoma).

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AcousticaBio is an advanced manufacturing company solving the greatest challenges in drug delivery for novel therapeutics. Today, millions of patients face the burden of frequent hospital visits, enduring painful, costly, and time-consuming intravenous (IV) injections to receive their life-saving medications. AcousticaBio transforms this process, making drug delivery as simple as receiving a routine flu shot. Utilizing advanced microparticle technology and our Harvard-patented acoustophoretic platform, we convert intravenously delivered biologic products into highly concentrated, small-volume subcutaneous injections – all without the use of solvents or cumbersome post-processing.

Research Area: Platform Technology Drug Delivery
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AIRNA brings together leading academic scientists that pioneered a new field of precisely targeting RNA. The company's medicines will be antisense oligonucleotides which are specifically delivered to target tissues and make precise modifications to alter the RNA or associated protein function, interaction, or form. The company has licensed a strong patent portfolio to be a leader in this emerging field.

Research Area: Drug Discovery / Development Oligonucleotide Drug
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Spun out of Prof. Ed Boyden and Prof. Bob Langer labs at MIT, Fragma Tx is revolutionizing the treatment of central nervous system disorders by transforming the blood-brain barrier (BBB) into a therapeutic delivery system. Our groundbreaking genetic therapy approach enables the BBB to produce therapeutic proteins directly in the brain, targeting diseases like Alzheimer's, Parkinson's, and multiple sclerosis with unprecedented precision. By addressing the longstanding challenge of drug delivery to the brain, we enhance treatment efficacy while minimizing systemic side effects. Fragma Tx is poised to bring this transformative solution to market, offering new hope to millions affected by debilitating neurological conditions.

Amplifier Bio

Amplifyer Bio, Inc. is a startup developing technology arising from a collaboration between the labs of Dr. Sangeeta Bhatia, Dr. Chris Love, Dr. Viktor Adalsteinsson, and Dr. Todd Golub at MIT and the Broad Institute. The work has been published in Science and has been presented at leading conferences both in the US and internationally. The company is focused on the development of novel priming agents that in combination with current liquid biopsy diagnostics will optimize test performance. Amplifyers first program will be focused on increasing cfDNA in blood for cancer diagnostics. This will provide both physicians and patients higher quantity and quality of genomic information related to their cancer, with the aim of improving clinical outcomes.

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Astro is focused on making immune silent gene delivery possible. Our platform is designed to enable safe delivery of DNA cargos for gene replacement, therapeutic intervention and genome writing.
 

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BioDevek leverages materials science, biology, and medicine to develop the next generation of biomaterial-based surgical solutions to improve the clinical outcomes following internal surgeries.
Research Area: Platform Technology Drug Delivery
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BrilliantStrings is an early stage medical device company that has developed a breakthrough approach to accelerate healing of damaged connective tissues based on the direct, controlled-delivery of functional protein (e.g. complete human collagen – CHC) to the injury. The company's technology, supported by decades of academic research, has been demonstrated in animals to rapidly restore the strength of torn tendons. There are multiple applications in the orthopedic space, with rotator cuff disease comprising the largest market and our first target indication. The therapeutic can be administered via injection as well as in other formats (e.g. patches).  With injection, BrilliantStrings has the ability to treat patients at a very early stage in tendon degeneration where no other competitor has a solution, expanding an already large market considerably. In addition, BrilliantStrings has developed and patented the CRISPR-based method to produce CHC, under extremely favorable economics, eliminating the complicated supply chain logistics of competing technologies.

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Cellforma

Life-saving donor lungs are a curative solution for many diseases but are extremely rare, and many patients die waiting for a donor lung to become available. At Cellforma we are using our pre-clinical proof of concept in mice and licensing a patent portfolio to develop first-in-class cell replacement therapy products to transplant and regenerate lung tissue, addressing the longstanding donor lung scarcity problem.

Logo of Cerberus Therapeutics, which is a biotech platform company developing innovative immunological solutions for antigen specific tolerance and infectious diseases.
Cerberus Therapeutics is pioneering an alpaca-derived single domain antibody fragment (VHH)-based platform to create novel therapeutics capable of immune modulation. Their initial programs focus on developing therapies for several autoimmune disorders, as well as tolerance against immune reactions to Adeno-Associated Virus ("AAV") vectors. By incorporating genetic and biochemical protein modification strategies, Cerebus has shown that just a single dose of these engineered VHHs achieve robust in vivo efficacy in preclinical mouse models of several autoimmune diseases including multiple sclerosis, type I diabetes, and rheumatoid arthritis, both prophylactically and therapeutically.
Research Area: Drug Discovery / Development Recombinant Therapeutic Protein
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Conveyor therapeutics aims to be the first company dedicated to expanding the knowledge of ADC design and development to novel payloads, targeting antigens, and indications. We seek to merge people, passion, and science to create therapeutics, which modulate intracellular targets with cellular precision, to restore health and save lives. Our next generation antibody drug conjugate (ADC) platform will expand the use of ADCs beyond oncology and traditional cytotoxic payloads to immunology and immunosuppressive payloads.  Conjugating payloads to an antibody offers a way to improve the therapeutic window of a given drug by directing it to the pathological cell type and reducing the level of systemic exposure of the free payload. With a few exceptions, most current generation ADCs are optimized for cell killing, which limits the applicability in areas outside of oncology. Limited development has gone into optimizing ADCs for other functions (e.g. interrupt kinase or transcription factor activity) or to have utility in cell types with lower expression of the targeted antigen.

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Corellia launched out of Champions Oncology, a technology-enabled contract research organization, leveraging the world’s largest PDX Atlas and its living bank for AI-enabled target and drug discovery.  Corellia is developing a large pipeline of innovative ADCs for patients with high unmet needs, at a pace and efficiency never achieved before.

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DaCapo Brainscience, Inc. is built to create revolutionary, disease-modifying therapeutics for neurological diseases. DaCapo is fusing a unique understanding of biological systems, their induced pluripotent stem cell (iPSC)-based neuronal culture systems, their proprietary analyses of patient databases, and their pioneering AI/ML algorithms to create an integrated platform for disease-definition and target discovery. With this platform, DaCapo Brainscience can identify novel molecular subtypes of disease and corresponding drug targets for synucleinopathies (such as Parkinson's Disease and Lewy Body Dementia) and other neurodegenerative diseases.
Research Area: Biological Product Cell Therapy
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ECI Therapeutics, LLC (ECI) is developing products from donated, pathogen-reduced human plasma. ECI's platform leverages serum-like plasma from donated human blood to promote the healing of epithelial (surface cell) disorders such as dry eye disease, ophthalmic burns, and chronic wounds. ECI has been issued robust patents protecting the formulation that combines serum-like plasma with a novel antimicrobial molecule (chitosan) to create products ranging from liquid eye drops to gels, ointments, contact lenses, contoured bandages, and wound dressings. 
ECI's initial product will focus on dry eye disease. There are 22 million dry eye patients in the United States and of those only 8 million are treated, with 25% reporting satisfaction with their treatment. There is a need for more effective treatments with fewer side effects. We intend to fill this gap while growing the percent of diagnosed patients seeking treatment.

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Epitope has identified specific sequence (epitopes) that lead to the generation of pathogenic antibodies, the underlying driver of a number of auto-immune disorders. Epitope's lead program uses a proprietary peptide display technology that will target and neutralise / eliminate the pathogenic antibodies, supporting patients who suffer Bullous Pemphigoid, a skin condition that one of the companies founders has been researching and treating over several decades.
Research Area: Drug Discovery / Development Small Molecules
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Evonik's strategic innovation unit and business incubator, Creavis, seeks to establish an innovation satellite to accelerate innovation in life science fields.
Evonik Health Care partners with the world's pharmaceutical, medical device and nutraceutical companies to transform complexity into value. Evonik is a leading system solution provider in nucleic acid-based medicine technologies. Research will include new excipients and delivery platforms to leverage the full potential of mRNA as a new therapeutic modality.
Many of the world’s largest and most innovative biopharmaceutical companies partner with Evonik to optimize their media platforms and processes. Our broad portfolio of cell culture ingredients and related services leverages six decades of industry leadership in highly purified amino acids. Research will include new technology platforms for cell culture media outside of dipeptides.
Evonik corporate venture capital will partner with the research team in Cambridge.

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Our aim is to develop a novel domain for immune recruitment for bispecific T cell engagers that specifically recruits immune cells in an activated, cytotoxic state. To do this, we are designing therapeutics that mimic antigens from common infectious diseases. In effect, our therapeutics will direct potent, existing immune responses for an infectious disease (e.g. SARS-CoV-2, influenza) towards a cancer, leading to a more precise and efficacious response.
Research Area: Drug Discovery / Development Recombinant Therapeutic Protein
Flux Tx

Unique propriatary platform technologies overcoming current limitations in gene therapy

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GelMEDIX is a platform-based company focused on developing bioadhesive hydrogel drug depots to improve patient compliance and treatment outcomes in ophthalmology. GelMEDIX was founded based upon 8 years of academic work originating at Massachusetts Eye and Ear, Harvard Medical School, Northeastern University, and UCLA that was motivated by challenges in post-op and chronic treatment in ophthalmology.
Research Area: Biological Product Cell Therapy
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Coming Soon
Research Area: Drug Discovery / Development Recombinant Therapeutic Protein
Logo of Gensaic, a LabCentral resident company which specializes in unbiased discovery and generative protein design, enabling precise delivery of therapeutic payloads to specific tissues, cells, and subcellular compartments.
Gensaic is a phage-derived particle (PDP) gene delivery platform that addresses key limitations in the current gene therapy landscape. Unlike the market lead AAV technology, PDPs offer durable therapeutic efficacy via repeat administration, enable tissue-specific targeting, support massively scalable manufacturing, and can package any full-length human gene as a therapeutic (>20 kb).
Research Area: Biological Product Gene Therapy
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Harton is an early-stage biotechnology company formed with the vision of transforming healthcare, therapeutics, and diagnostics, through our iterative design, build, test platform. Our platform designs modular engineered proteins and cells via AI, builds at unlimited scale using synthetic gene libraries, and continually tests on patient samples utilizing all forms of sequencing from next-gen sequencing, to single-cell, to spatial. Harton's mission is to transform healthcare by delivering next-generation precision-engineered therapeutics linking cellular and targeting discovery technologies to advanced therapeutic designs. In the future, libraries of characterized modular therapeutic components will enable rapid development of safe & effective personalized drugs.
Research Area: Biological Product Cell Therapy
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HDAX Therapeutics is on a mission to revolutionize the treatment of neurological and cardiovascular diseases driven by microtubule dysfunction through our best-in-class, disease-modifying therapeutics. By targeting the disease driver HDAC6 through our novel, proprietary 2-site binding mechanism, we aspire to target the root of diseases, to create solutions that bring lasting benefits, enabling patients to thrive and live life to the fullest.

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HydroGene has a mission to bring gene therapy to all liver diseases. This can be accomplished with non-viral gene delivery, which would be safe, cheap, and redosable. Unfortunately, non-viral gene delivery with lipid nanoparticles has suffered of inefficiency from nuclear delivery of DNA cargo. As an alternative, HydroGene has solved how to scale hydrodynamic delivery inot the liver of large animals for the first time by leveraging the biliary system. HydroGene's approach is efficient, scalable, and safe in porcine and primate models and has exciting potential to treat rare and common diseases.

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Biologics command a large share of the therapeutics market but are limited to injection-based therapies due to poor oral bioavailability. This administration route results in increased healthcare costs and poor patient compliance. i2O Therapeutic's ionic liquid platform enables the oral delivery of such drugs, alleviating the patient burden for these therapies.
Research Area: Platform Technology Drug Delivery
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Ilios Tx is a small molecules drug discovery platform that creates first-in-class disease-modifying drugs to treat neurodegenerative diseases.
Research Area: Drug Discovery / Development Small Molecules
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InGel Tx technology is an injectable biomimetic hydrogel platform engineered for the sustained release of stem cells and drugs in the eye, initially targeting regenerative medicine for retinitis pigmentosa, macular degeneration and geographic atrophy.
Research Area: Biological Product Cell Therapy
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InnDura develops Armed Cytokine-Induced Memory-Like NK cells (CIML NK cells). In clinical trials CIML NK cells have been shown to have significantly enhanced properties of potency, proliferation and persistence when compared to conventional NK cells, whilst retaining their excellent safety profile when compared to CAR-T therapies. Using InnDura's proprietary NAS-CAR manufacturing, InnDura can genetically engineer these CIML NK Cells to further enhance their efficacy against a range of hematologic and solid tumors. InnDura's platform technology thus delivers benefits over both CAR-T therapeutics and conventional NK cell therapeutics.
Research Area: Biological Product Cell Therapy
Interon laboratories
Coming Soon
Research Area: Drug Discovery / Development Small Molecules
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K2B is a pre-clinical stage therapeutics discovery startup, with the goal of commercializing a game-changing protein-RNA conjugate in the immune-oncology space.
Research Area: Biological Product Gene Therapy
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Kano Therapeutics believes that innovative drugs need innovative supply chains. Kano is building a bio-infrastructure company to solve the huge bioprocessing capacity crunch in therapeutic manufacturing for cell and gene therapy companies. Kano's immediate focus lies on a new type of genetic vector for CRISPR applications that enables their customers to get their innovative drugs faster in and through clinical trials.
Research Area: Biological Product Gene Therapy
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Kern System's mission is to provide the first permanent data archive infrastructure for the rapidly expanding digital universe. Kern Systems will offer customers a cost-effective way to archive data without material risk of loss, overheads associated with data maintenance, and obsolescence.
Research Area: Platform Technology R&D Tool
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Kernal Bio is a biotech company developing mRNA 2.0 immunotherapies. Kernal mines translatome data to discover cell-specific sequence features and design mRNAs that are selectively translated in cancer cells. These mRNAs are formulated with proprietary, best-in-class LNPs validated in non-human primates. Our development candidates have a remarkably wide therapeutic index and can be systemically delivered with extrahepatic LNPs. Lead program shows high efficacy and safety in solid tumors resistant to other immuno-oncology agents. With roots at MIT, Harvard, Merck and BMS, Kernal’s management team has deep expertise in mRNA therapeutics with three FDA approvals and 120+ patents. Based in Cambridge, MA, the company is backed by Hummingbird, Amgen, HBM, Civilization Ventures, NASA, and Boeing.

Research Area: Drug Discovery / Development mRNA
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Kestrel focuses on approaches to inhibition of mutated RAS protein in a variety of cancers. We use chemical screens, structural biophysical approaches, and medicinal chemistry to identify and characterize candidate inhibitors. We have four employees, have just been authorized to use our second tranche of funding, and are expanding.
Research Area: Drug Discovery / Development Small Molecules
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Lightcast's platform enables highly multiplexed single cell functional screening with optical control over tens of thousands of droplets with flexible cargos, allowing for droplet merges, imaging, selection and dispense.

Lightning Therapeutics

Sparking immune regeneration via thymus regeneration.
1. Lightning Bio uses deep knowledge of immune cell generation and bioengineering to restore immunity damaged by toxins, disease, or age
2. Lightning Bio leverages the body's inherent regenerative capacity to create novel therapeutics for immune dysfunction
3. Lightning Bio's science works to replenish T cell diversity through modification of the body's cell factories

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Limax Biosciences is developing a strong and flexible hydrogel adhesive for wounds inside and outside the body
Mab Lab

MabLab is building 5-in-1 test strips to detect the five deadliest lacing agents in recreational drugs.

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Coming Soon
Research Area: Biological Product Cell Therapy
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Spun out of Harvard and MIT and backed by Versant Ventures, March Therapeutics ("March") is advancing molecular recording, genome mining and AI/ML to identify novel enzymatic activities from the tree of life and repurpose them for therapeutic applications.
Research Area: Biological Product Gene Therapy
Materialize Bio

We are Materialize Bio, the groundbreaking medical device company revolutionizing the field of implants. We recognize the limitations of current commercially available implants, which fail to meet various clinical needs due to material and manufacturing constraints. But we have the solution.

Imagine implants with tunable degradation, precisely aligning with soft tissue healing within days or months. Or implants that can degrade 'on command' when they are finished serving their purpose. Our 3D natural polymer-based implants have the potential to prevent post-surgical complications like infections and scar formation, eliminating the need for additional surgeries.

What sets us apart is our ability to harness the unique properties of natural biopolymers, which possess remarkable antimicrobial, biocompatibility, and degradation features. While others have been able to create 2D films or threads, our core team has developed intellectual property that allows Materialize to manufacture and scale these materials into complex 3D structures efficiently and reproducibly.

But that's not all. Our implants can also incorporate functional drug delivery, overcoming the challenges of incorporating drugs into synthetic or biologic materials. We are equipped with innovative methods to enable drug release within our 3D implants, allowing targeted and controlled delivery that offers potential to enhance patient outcomes.

At Materialize Bio, we are pioneering the future of medical implants. Join us on our journey as we redefine possibilities in implant technology, offering unprecedented degrade "on demand" potential and functional drug delivery. Together, let's transform the landscape of healthcare and improve the lives of countless patients worldwide.

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Matrisome Bio is developing tools to deliver targeted therapies to the extracellular matrix (non-cellular components) of disease tissues such as tumors and fibrotic lesions in order to convert it from a barrier to a drug depot.
Research Area: Platform Technology Drug Delivery
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Meliora is focused on developing mechanism-driven cancer drugs. We use our computational mechanism of action deconvolution platform to identify the true MOA of molecules, and develop higher probability of success clinical assets.

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NextPoint is advancing the field of immuno-oncology through its leading scientific work on the novel HHLA2 pathway. Their innovative approach integrates foundational science with a defined clinical biomarker to deliver a new class of monotherapies for patients who will not benefit from PD-1/L1 inhibitors.
Research Area: Drug Discovery / Development Recombinant Therapeutic Protein
Novilla Pharmaceuticals is an early-stage biotech company developing two disruptive technologies developed by a former Harvard professor. Their programs utilize a precise delivery mechanism platform that uses charged ions to deliver medications through the intact dermal layer directly to nerves and other deeper tissues, which has not been possible before without the use of electrophoresis.
Research Area: Platform Technology Drug Delivery
Nucyrna
Omnipulse Biosciences

We will be developing injectable microparticles containing drugs (vaccines, other API's) that have programmable release kinetics and time points. These microparticles provide self-boosting vaccines, replace multiple injections with a single injection, and also enable long term storage of drugs without the need for cold chain.

Financed by Khosla Ventures, Pearl Bio brings together a broad patent portfolio from 15+ years of development in synthetic biology, genome editing, and ribosome engineering, converging in a new technology platform. Pearl's paradigm enables the biosynthesis of therapeutics and entirely new classes of biomaterials with novel genetically encoded chemistry incorporated with precision at multiple, distinct loci to produce precisely tailored biotherapeutics with tunable half-lives and reduced immunogenicity.
Research Area: Platform Technology R&D Tool
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The biotechnology companies that want to scale up their biologics manufacturing to advance development of therapeutics, either in house, or at at CRO, encounter practical scale up bottlenecks in low purity, high cost, excessive waste and often failure. Phorum AI addresses these practical hurdles with AI technology developed from real world experiments from the lab of Brad Pentelute at MIT for peptides. The technology has been proven in peer reviewed journals to predict and suggest better purification approaches and amino acid substitutions to enable successful peptides and potentially lower costs for the company.

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The potential for cell therapies to address a myriad of diseases like cancer, autoimmune disorders, and neurodegeneration is exponentially increasing. However, the field is still devoid of  scalable cell modification tools that don't disrupt cell viability and mediate efficient delivery of exogenous cargos. Portal is addressing this unmet need by developing mechanoporation-based cellular delivery systems for efficient delivery of cargos like mRNA, proteins, and DNA, indiscriminate of cell type. Our goal is to implement a universal basis for cell engineering, to simplify the production of cell therapies, and further expand the cell therapy field's impact by creating libraries of RNA cell modifications. 

Coming Soon
Research Area: Drug Discovery / Development Small Molecules
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Prox Bio is a Seed-stage biotechnology company developing conditional biologics across immunology. We use next-generation immunology, antibody engineering, and computational methods to control biological pleiotropism. Prox was founded and financed in early 2024 by world-class scientists from UCSF, Alloy, Stanford, Penn, and MIT, and leading biotech investors.

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Coming Soon
Research Area: Drug Discovery / Development Recombinant Therapeutic Protein
Logo of QurCan Therapeutics, which is a biotech company that focuses on the discovery and development of breakthrough therapeutics enabled by its ​proprietary nanoparticle drug delivery technology called “TERP”.
QurCan Therapeutics solves the problem of CNS and tissue-specific delivery of nucleotide and therapeutic molecules via its proprietary next generation nanoparticle platform, called "TERP". QurCan's team is committed to restoring health and transforming the lives of patients through the development of nanomedicine that requires the unique features of the TERP technology to address major unmet needs for the treatment of cancer and other major diseases.
Research Area: Platform Technology Drug Delivery

RASyn is developing a suite of integrative technologies, leveraging unparalleled high-throughput sequencing, cell free protein synthesis and functional screening coupled with computational protein design and machine learning. RASyn's platform will power predictive diagnostics analytics, enhance novel target discovery as well as unlock novel therapeutic design spaces across multiple modalities.

For the human body to develop and function normally, the precise level of expression of each gene of the genome needs to be tightly regulated by epigenetics. When this balance is disrupted, alteration in gene expression can lead to severe genetic diseases for which no cure is available. Regel’s technology utilizes a deactivated Cas system (dCas) which targets the epigenome without editing or damaging the DNA. This approach harnesses the natural mechanisms of gene regulation, allowing for efficient and permanent restoration of normal gene expression.
Research Area: Biological Product Gene Therapy
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Coming Soon
Ribonaut Therapeutics is developing a novel small molecule platform capable of specifically degrading RNAs for the treatment of human diseases. Ribonaut's approach leverages the work of academic founder, Matthew Disney - Chair of the Department of Chemistry at Scripps Florida, and his foundational insights into the targeted recruitment of RNAses to specific RNA structural motifs using small molecules.
Research Area: Drug Discovery / Development Small Molecules
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Riboway therapeutics is based in Boston area and focuses on drugging RNA regulation in the CNS to flexibly control the target, including up-regulation, down-regulation, function activation & inhibition. Our proprietary LEVERAGER platform decodes RNA regulation information and enables development of smart ASOs to re-direct the fate of RNA. This is not achievable with other RNA modalities and our use of a clinically derisked chemistry provides potentially superior safety profile. 

Lead program L0004 is the first known molecule to directly activate the function of NRF2, a highly sought-after transcription factor target for treatment of a variety of diseases. We are developing the program for neurodegenerative diseases and our strategy could be a game changer for the field. While our second program addresses another large market with significant unmet need, cachexia, by targeting a pathway that drives systemic metabolic maladaptation. 

All our programs exploit novel, druggable RNA processing mechanisms. We are currently raising series A as well as looking for partnership/BD out-licensing opportunities.

Logo of Rubik Therapeutics, which is an early-stage biotech pioneering next-generation solid cancer targets and pan-checkpoint immune suppression control for both autologous or allogeneic solid tumor cell therapies.
Rubik Therapeutics is developing programmed CAR-T/NK cell therapies for solid tumors. We have identified a set of highly selective, exclusive solid tumor targets as well as T cell modulators that will allow us to treat solid tumors while avoiding toxicity and immune evasion.
Research Area: Biological Product Cell Therapy
Sintra

We are a non-viral genetic medicines company tackling delivery, targeting one of the more elusive organ systems, the kidney. By utilizing both untargeted and targeted approaches we plan to demonstrate efficient delivery to the correct cell types of interest in the kidney to provide functional cures for many devastating genetic kidney disease for pediatric and adult patients.

Skylark is pioneering gene therapies for patients with hearing loss.
Research Area: Biological Product Gene Therapy
Stipple Bio is unlocking cellular profiling and target discovery with epitope resolution.
Research Area: Drug Discovery / Development Recombinant Therapeutic Protein
Stratagen Bio is developing a novel class of sensors that provide quantitative and direct measurements of tissue oxygen, which are not possible with alternative sensors. Their sensor will enable more personalized and effective treatments for patients in a wide range of applications including oncology, wound healing, and tissue transplantation.
Research Area: Medical Device Diagnostic Device
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Synolo Therapeutics, an early-stage biotechnology company launched by RA Capital, is pioneering the development of precision-targeted immunotherapies for cancer. Powered by computational protein design and proprietary technologies which yield biological data sets at unprecedented scale and resolution, we are building a pipeline of first-in-class multi-specific biologics with novel functionalities. Synolo was founded by pioneers in the field of protein design and engineering, synthetic biology, DNA sequencing, immunology, and biologics drug discovery and development.  

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Tevard Biosciences is a pioneering tRNA-based gene therapies to cure rare and severe genetic diseases with limited or no approved treatment options. Tevard was founded by MIT Professor and Whitehead Institute Founding Member Harvey Lodish, with life science entrepreneurs and executives Daniel Fischer and Warren Lammert, fathers of children with Dravet syndrome.
Research Area: mRNA
Logo of Transcera, which a founder-led, venture-backed biotech company formed in 2021 to translate discoveries about biologic medicine delivery from the Lencer and Chinnapen labs at Harvard Medical School and Boston Children’s Hospital.
Transcera is transforming chronic disease treatment through a new approach to biologic medicines. Our novel lipid-based platform enables oral absorption and amplified distribution of large molecule therapeutics, so we can turn injections into pills and deliver biologics to hard-to-reach tissues such as the brain.
Research Area: Biologic Medicine
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Coming Soon
Research Area: Cell & Gene Therapies

Typewriter's technology will further expand current genome editing toolbox. More importantly, the technology possesses advantages over other existing editing methods and has potentials to address many unmet needs to cure diseases.

Research Area: Cell & Gene Therapies
Viska.Bio Therapeutics induces Immunogenic Cell Death by treating cancer with a Fusion Protein between a tumor specific antibody and the enzyme Xanthine Oxidase. This produces superoxide in the tumor microenvironment oxidizing lipids which are incorporated into the lysosome which then becomes leaky releasing degradative enzymes which induce endopepsis - or cellular internal digestion. One result is that calreticulin, the eat me signal for DCs, migrates to the cell surface initiating the immunogenic feature. ODIN Therapeutics has produced a fusion protein to EGFR and shown that it produces the classic markers of Immunogenic Cell Death.
Research Area: Drug Discovery / Development Recombinant Therapeutic Protein
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We are biotech venture builders with decades of experience in cell & gene therapies. We scout for novel ideas and breakthrough technologies, and we invest in those with disruptive, high-value potential. With focus on product development and manufacturing innovation, we provide both capital and operational expertise to our ventures. Our goal is to accelerate their progress, ensuring they achieve preclinical proof-of-concept and clinical validation. Our hub-and-spoke model optimizes resource allocation by centralizing capital, expertise, and talent across multiple assets. This efficient approach enables us to drive projects towards value inflection points while minimizing costs. By mitigating clinical risks and validating our ventures' commercial potential, we create substantial value for our investors and patients alike.

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Vrata Therapeutics is developing a cell-penetrating antibody capable of delivering nucleic acid cargo directly to the cytoplasm of cells, especially in post-mitotic tissue such as skeletal muscle. This antibody allows avoidance of the endosomal escape problem, which severely limits the amount of nucleic acid therapeutic that actually gets to the site of action in the cell.
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WhiteLab Genomics is a pioneering startup leveraging Artificial Intelligence to accelerate and mitigate risks in early-stage research and development pipeline for genomic medicine. We are actively engaged in partnerships with renowned academic institutions (Genethon, Brain Institute), as well as small and mid-sized biotech (Flagship Pioneering, SIREN biotech) and pharmaceutical companies (e.g. Sanofi), aimed at addressing critical challenges in the biopharma industry for target discovery, payload, and vector engineering and bioproduction. We are collaborating with Sanofi to develop new gene therapies in ophthalmology (targeting microglia in the CNS) and rare disease.
By bringing together the power of computer sciences (e.g. ML, GenAI) and biology, we help our partners to reach their target product profile, faster, in leaner ways. We have developed a proprietary platform including algorithms and databases to improve the design of therapeutic candidates for enhanced safety and efficacy. It includes vectors optimisation such as adeno-associated virus (AAV) and lentivirus, or non-viral like LNP. WLG synergistically combines in-house biomarker cellular atlas, computer science techniques with bioinformatic methods like transcriptomic analysis and structure prediction. WLG employs computational and structural biology to predict the most pertinent receptor-ligand interactions for specific targets, be it organs or cells. For instance, in the context of improved AAV transduction, WhiteLab strives to identify membrane-associated receptors and ligands that are highly specific to a tissue as a potential target. A key differentiator regarding our approach is that we can identify biomarkers that are highly specific to a cell type in over 850 cells in the body. This enables our AI platform to design the best vector to bring the right therapeutic sequence into the cells expressing a specific phenotype.

Zag Bio is developing therapeutics targeting the thymus to treat autoimmune diseases and patients with transplants. The thymus trains T cells to tell the difference between self and non-self and plays a critical role in the development of autoimmune disease. The company is developing therapeutics to train tissue-specific T regulatory cells to enable tolerance induction. There are currently no drugs that target the thymus.